Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Biological and Medical Physics, Biomedical Engineering) (英語) ハードカバー – 2015/11/18
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This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
“This text concerns protein conformational aberrations and expression in the following diseases: Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, etc. … The book is primarily for physical chemists and researchers having an interest in the molecular mechanisms of neurological diseases.” (Joseph J. Grenier, Amazon.com, March, 2016)商品の説明をすべて表示する
Springer Cham, Berlin Heidelberg New York
J Grenier MD PhD
This text concerns protein conformational aberrations and expression in the following diseases: Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, etc. The biophysics and biochemistry of these disorders is described in color drawings. The role of enzymes, changes in gene expression, and chaperone molecules are discussed. The thermodynamics, quantum physics, and changes in entropy of these proteins are examined. The book is primarily for physical chemists and researchers having an interest in the molecular mechanisms of neurological diseases.