The End of Alzheimer’s: The First Programme to Prevent and Reverse the Cognitive Decline of Dementia (英語) ペーパーバック – 2017/8/22
Kindle 端末は必要ありません。無料 Kindle アプリのいずれかをダウンロードすると、スマートフォン、タブレットPCで Kindle 本をお読みいただけます。
The first proven plan to reverse Alzheimer’s Disease. In The End of Alzheimer’s Dr Dale Bredesen offers real hope to anyone looking to prevent and even reverse Alzheimer’s Disease and the cognitive decline of dementia. Revealing that AD is not one condition but in fact three, he outlines 36 metabolic factors, including micronutrients, hormone levels and sleep, which together can trigger downsizing in the brain.
Dr Bredesen then outlines a proven, step-by-step protocol to rebalance these factors, which patients can follow with the help of a healthcare professional (note: blood tests are required in order to tailor individual plans). There are also general lifestyle and dietary changes all readers can adopt to improve cognitive health.
- Rewrites the science of Alzheimer’s Disease
- Proven step-by-step advice to follow with your doctor
- Offers real hope to patients, carers and health professionals
- The first major breakthrough to stop Alzheimer’s in its tracks
Survival rates in many life-threatening conditions, such as cancer, have been steadily improving for years. But until now nobody had ever survived Alzheimer's Disease. The results, however, of Dr Bredesen’s protocol are impressive: of the first ten patients on the protocol, nine displayed significant improvement within three to six months; since then the protocol has yielded similar results with hundreds more. Dr Bredesen is also focusing on training UK healthcare professionals in his protocol with a further 200 professionals set to receive training this coming spring.
"The End of Alzheimer’s is a phenomenal book. Dr Dale Bredesen’s research is some of the most exciting work that I have seen in years and tackles the most important health issue of our time. It helps us understand this complex and devastating condition but is also the roadmap to prevent it in the first place. By tackling arguably the most important disease of our age, Dr Dale Bredesen is actually changing the way we look at all chronic disease. This is a masterpiece and a must-read book." (Dr Rangan Chatterjee, MRCP, MRCGP, author of 'The Four Pillar Plan')
"The End of Alzheimer’s is a monumental work. Dr Bredesen completely recontextualizes this devastating condition away from a mysterious and unsolvable process to one that is both preventable and, yes, reversible." (David Perlmutter, MD, author, #1 New York Times best seller, Grain Brain, and Brain Maker)
"The End of Alzheimer’s is a masterful, authoritative, and ultimately hopeful patient guide that will help you prevent and reverse Alzheimer’s disease, whether you have the ApoE4 gene or not. My patients fear Alzheimer’s more than any other diagnosis. This is the book to transmute fear into action." (Sara Gottfried, MD, author of the New York Times best seller Younger)
"Dr Dale Bredesen is a world-class neuroscientist/neurologist who through his innovative and exacting research has discovered a safe and effective approach to the prevention and treatment of Alzheimer's disease that will revolutionize the way we think about the disease." (Jeffrey Bland, PhD, Founder of the Institute for Functional Medicine)
"Dr Bredesen has provided enormous hope for the heretofore intractable clinical problem of Alzheimer’s. Bredesen’s early studies suggest that this approach can halt and in many cases reverse early Alzheimer’s." (Leroy Hood, MD, PhD, Winner of the National Medal of Science from President Barack Obama, and Founder, Institute for Systems Biology)
"Every citizen and medical professional interested in the brain and its health should read this seminal book. It should provide much of the basis for a true revolution in brain health medicine." (Michael Merzenich, PhD, Winner of the Kavli Prize in Neuroscience)
"A must read for anyone wondering what can be done for this dread disease, whether for themselves, a loved one, or a patient. " (Nathan Price, PhD, Professor & Associate Director of the Institute for Systems Biology)
"Having spent several years implementing many of Dr. Bredesen's insights in my patients, I can assure you that following his advice can save yourself, your loved ones, and your friends from suffering from this preventable and reversible curse." (Steven Gundry, MD, Medical Director of The International Heart and Lung Institute and author of the New York Times best seller The Plant Paradox)
"This book represents a major turning point in our approach to Alzheimer’s disease. For the first time ever, patients and families affected by Alzheimer’s―as well as those at high risk for this devastating disease―truly have a reason to be hopeful." (Chris Kresser, MS, LAc, author of the New York Times best seller The Paleo Cure)
"The End of Alzheimer’s offers a new beginning in Medicine. Dr Bredesen translates the knowledge of science to the wisdom that helps to heal our people . . . and provide a vision for the end of Alzheimer’s." (Patrick Hanaway, MD, Founding Medical Director, Director of Research, Center for Functional Medicine, Cleveland Clinic)
Dale Bredesen, MD, is internationally recognised as an expert in the mechanisms of neurodegenerative diseases, such as Alzheimer's disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, North Carolina. He served as chief resident in neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner's laboratory at UCSF as an NIH postdoctoral fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr Bredesen directed the Program on Aging at the Burnham Institute before joining the Buck Institute in 1998 as its founding president and CEO. He is Professor of Neurology at the University of California, Los Angeles.
I first heard of the Bredesen Protocal last winter, when Maria Shriver discussed it on the Today Show. I quickly researched it as much as possible, but info was limited. I had a feeling a book was forthcoming, so I anxiously awaited it's release. I was worried The End of Alzheimer's would contain too much technical information that I might not be able to understand. I was very happy to see that it was written in a casual format that intentionally makes it easier for the rest of us. The details are clear, the tone is casual, and it's easy to follow.
As I read through this book, I was surprised by how many points were familiar to me. That's me! I do that! Oh heck! It was as enlightening as it was scary. Living with Mom, I also live in fear because I know I'm on the same path she struggles down every day. That's my future.
On page 97, Bredesen says "How to give yourself Alzheimer's. Live your life in a way that keeps your brain supplied with as many as possible of the 36 factors that influence whether APP gets cut into the destructive quartet or the beneficial duo. How to prevent it. Live your life in a way that minimizes the number of the 36 inducing factors in your brain." Those 36 factors are clearly laid out and I believe they are not difficult to control.
Several years ago, I struggled with brain fog and often had difficulty remembering numbers for even a couple of minutes. I also was overweight and had heart problems. I reached a point where I thought I would die, so I wrote my will and made plans for my dogs after I was gone. Then I said enough was enough, and I dramatically changed my lifestyle. I cut out processed foods, ate lots and LOTS of vegetables and fresh fruits, especially leafy greens and berries. I ate wild caught fish, but no other animal products. My diet was low in grains. I used the USDA Super Tracker to make sure that my diet exceeded the RDA for every nutrient they tracked. There's a lot more to it, but I was eating all the time and I exercised every single day. Within a few weeks, I had much more energy. Within a few months, my brain was on FIRE! But then...
I started a new job and everything about my lifestyle and schedule changed. Long story short, I fell back into old habits, abandoned my perfect diet and exercise program, and gradually regained weight. I also started losing clarity and life became more difficult. I recognize that. And I know that I alone can change that.
I'm so very glad to have read the Bredesen Protocol because I know now, more than ever, the importance of getting back on track. I am making a serious effort to change my future. I believe this book can help. I have already marked my calendar and plan to follow up on this review in 3 months and again in six months. Mom may be too far along, I don't know, but it's worth trying for both of us. Dr. Bredesen states in the book that his protocol may not work for frontal lobe and other types of dementias. It has only been tested on Alzheimers. I feel that it's still very important to heed his advice, as Alzheimers often doesn't get a definite diagnosis until after death.
Why is this an important issue? Because we have a tsunami of Alzheimer’s disease approaching on and it is on track to take the lives of 45 million of the 325 million Americans alive today. It’s currently the third leading cause of death in the US and is costing the United States over $220 billion annually. It is a trillion-dollar global health problem. It was the sixth leading cause of death
Dr. Bredesen is uniquely qualified to write this book as he has spent most of his three decades as a physician in this field and was trained at Cal Tech and Johns Hopkins. He is the director of Neurodegenerative Disease Research at the University of California, Los Angeles (UCLA) School of Medicine, He has identified a number of molecular mechanisms at work in this disease, and has created a novel program to treat and reverse it that he calls ReCODE (Reversal of Cognitive Decline)
Many are concerned about this disease and have had themselves tested for the genetic risk factor Apolipoprotein E epsilon 4 (ApoE4). An estimated 75 million Americans have the single allele for ApoE4. Those who are ApoE4 positive have a 30 percent lifetime risk of developing the disease. Approximately 7 million have two copies of the gene, which puts them at a 50 percent lifetime risk.
One of the highlights of the book is his strategy of how to actually reverse ApoE4 damage. This can be done by simply implementing intermittent fasting and restricting your eating window to 4-8 hours a day. This is because ApoE4 appears to be a gene that all ancient humans had and it provided an metabolic advantage for those that were regularly going without food and fasting for periods as was common in ancient times. Individuals that had this gene would actually live longer as they could more easily switch between fat and carb burning. This knowledge can help you actually reverse the damage that most of us acquire when we inherit this gene by merely implementing intermittent fasting.
His ReCode program discussed three dozen different tests that one can screen for and if they are abnormal they can be addressed to improve the synaptic balance to a more healthy level and reverse or radically reduce the risk of Alzheimer’s. If you ever had any concern about Alzheimer’s there is no question in my mind that this is the book to get. Strongly recommended.