Analytical Techniques in the Pharmaceutical Sciences (Advances in Delivery Science and Technology) (英語) ハードカバー – 2016/11/22
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The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering.
Anette Müllertz is professor in the Department of Pharmacy, University of Copenhagen, Denmark. She is head of Bioneer:FARMA, funded by the Danish Ministry of Science and Technology to establish research-based scientific services within the area of Drug Development. After receiving her PhD degree in lipid nutrition at the Technical University of Denmark, she worked for Novo Nordisk A/S, on the development of e.g. structured lipids, digestive lipases, and digestion models. Now, at the University of Copenhagen, she is head of the Rational Oral Drug Delivery Research Group, which focuses on developing predictive biopharmaceutical tools for oral drug development and lipid-based formulations. She has contributed to over 130 publications in international peer-reviewed journals and 10 book chapters. She is also a winner of the AAPS Lipid-Based Drug Delivery Award.
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