I ended up going with the Espionage, basically, out of default. Here are my thoughts:
Rolltop: After using this for about 2 months, I wouldn't classify this as an ideal "rolltop" backpack (not that Timbuk2 markets it as a rolltop). It's best used as shown in the photos, although I'll roll it up on occasion. Things just seem more secure to me when the top is rolled. The reason it doesn't roll in the ideal way, is because the top section isn't lined with velcro.
Size: The pack can fit a small amount of gear. But if modified a bit, and if you're willing to play a serious game of Tetris, you can fit a decent amount. With a camera bag insert (I used an 11"x 11" x 5" insert from F-Stop Gear) I was able to fit 2 bodies, and 3 lenses in the lower compartment (a Mark ii with a lens attached, and a Mark iii with a lens attached). You'll have to unzip the divider between the camera compartment, and the rolltop compartment to fit the insert.
The top will fit a light jacket and a few other small items.
Comfort/Straps: This thing is VERY comfortable, even when stuffed full. The straps aren't overly padded (I don't like when they're too bulky), but the foam inside just feels nice.
Build Quality: As with all of Timbuk2's products, this thing is built incredibly well. I envision it lasting for years, even with daily use.
Fit: I'm a 5' 8" man, with a pretty normal sized torso. I wear my backpacks pretty high. This pack (when filled with a normal amount of stuff - particularly in the top compartment), is at about shoulder level, at the top, and about 4" about the top of my butt. It's a pretty tall backpack, but only when the rolltop is filled.
1. The amount of compartments for accessories is pathetic. There are some puny little divider things in the rolltop compartment. I wouldn't put anything important into them, like batteries or memory cards, because they'll likely fall out.
There is a small side pocket on the outside of the backpack that will fit about 3 Cliff Bars. Don't even think about putting a water bottle in it. You'll have to put that inside the backpack (which means you won't be able to bring that water bottle with you).
The front/outside compartment won't fit much, and because the zipper is so tight, and it's so deep, anyone with big hands will almost get their hand stuck in there searching for anything small that has found it's way to the bottom.
The inside compartments are ok. They're a mesh, which is fine with me, and they'll fit a decent amount of nick-nacks. What I hate about it, is the zippers seem upside down to me. If you aren't planning on opening the front lid all the way open (you'll have to lay it flat to do so), stuff form the pockets will come spilling out.
The small, soft compartment in the front is almost too small to fit anything. I put a pair of sun glasses in, but they ended up getting smashed when the backpack was full. Still nice for keys, etc., but the size makes the soft cloth almost pointless.
2. The lack of straps on the outside of the backpack (the side with the side pocket) is a bit annoying. I tend to strap lens bags to the outside of my camera bags, but you can only do it on the side with the tripod straps. So if you've got lens bags on that side (with lenses in them), the backpack fits very awkward/lopsided. I wish Timbuk2 had added more outside straps, which would help make this thing a bit more modular, and, at least tolerant, of the lack of compartments.
Conclusion: If you're a street photographer, and you're planning on having one camera a lens or two, and you're using this as an everyday backpack I would say this is a pretty cool backpack for you. It's VERY minimal, so don't plan on keeping a bunch of your things in it, though.
If, like me, you're a professional photographer, and plan on using this even using this on quick shoots, I would either wait for another rolltop backpack to be released, or just look for a larger non-rolltop backpack. The lack/size of the compartments are one of my only real complaints, but with the importance of accessories when shooting, for realistic photography situations, this is a pretty big deal.
I'm still using this pack right now, but only for VERY short/small shoots, and day trips where I'm shooting for myself (without any lighting).
-I wanted a backpack instead of an over-the-shoulder case because I find that a backpack is far more comfortable when walking long distances
-I was specifically looking for a case that had space for a laptop as well as non-camera related items. When I'm taking the bag with me on a plane I don't want to fully lose one of my carry-on bags to camera equipment. Further, given that this will be the bag I'm storing underneath the seat in front of me, it needs to have space to hold whatever I might want easy access to during the flight, such as a water bottle, food, books, iPad, magazines, jacket, phone charger, etc. Most of the backpack camera bags I looked at had suprsingly little room for non-camera equipment (except for a laptop).
The attached video gives a good idea of how much the bag can hold -- I've loaded it up and then unpacked it.
-Tough, rugged construction. No doubt that it can take a beating and protect my camera.
-Even with a large body camera it should be able to hold three lenses (not including the lends attached to the camera).
-Holds laptop and has a good amount of space for non-camera equipment.
-Comes with rain cover; can hold tripod.
-Most of the accessory pockets are ridiculously small. For example, the pocket meant for cell phones can barely fit an iPhone 5.
Overall I think this is an excellent bag, but the MSRP price is pretty steep. If it wasn't for the fact that I was able to get the bag for 40% off the MSRP thanks to a one day sale, I would have purchased one of Timbuk2's cheaper camera bags, such as the Sleuth or Snoop. Despite the high price, I'm still going to give the Espionage five starts because it is such a well made camera bag.
The camera and lens compartment is spacious and customizable, allowing me to fit up to 4 lenses, microphones, my viewfinder, a canon 600D and a Black Magic Pocket Cinema Camera. The top rolled compartment has room for a fluid head, all my cords, some snacks, and any other random items I have on me for the shoot that day. A padded laptop area makes this backpack an all-around mobile workstation for video, photography, and post-production.
The tripod straps hold my Manfrotto 190C perfectly, never come loose and it allows for the easiest transportation of a tripod that I can say I've used. The front pocket is super nice for papers or other thin items. Adding a bottle opener and water bottle pocket just adds to the appeal of this backpack. The only qualm I have is the padded pocket for cell phones is a bit too small for my Nokia Lumia 1020.
As a traveling camera backpack, it is bar none the best I've ever used. Even biking with this baby full of 40 pounds allows for a comfortable affair. If you're moving around or looking to have your camera on you to never miss that moment when you need it, this is the backpack for you.
What came with this bag was really something I didn't expect - I could put 1 body and 2 lens for my travelling photography, and also another lens or body with the other above-mentioned items in the big space above the camera slot. Utterly durable and being able to hold a tripod as well, I will recommend this to anyone who owns a DSLR and always travels around. It's not too bulky, and not too heavy and the amount of space is astonishing.