I suspect that if this book is half as successful and influential as "The Innovator's Dilemma" (by Clayton Christensen, one of this book's three authors), then people will be quoting "The Innovator's DNA" for a long time. (If you haven't already read "The Innovator's Dilemma," I certainly recommend it, although it isn't a prerequisite.)
It is interesting that the authors chose "The Innovator's DNA" as their title, because when I think of DNA, I think of that which is hard-wired within us. However, perhaps the key point of this book is that our ability to create innovative ideas is not simply a function of the hard-wiring in our minds, but also an important function of our behaviors. This important point is based on the authors' extensive research (see below), which also shows that innovative companies are almost always led by innovative leaders. By the way, it's business creativity that the authors address, not artistic creativity.
So if we want to help start (or simply identify) innovative companies, we should focus on their leaders' behaviors. That's what constitutes the main thrust of this book. Through many interviews and detailed research the authors collected data from hundreds of innovators and thousands of executives (more data is on the authors' website), looking for the origins of innovative business ideas. The results of their study were first published in a leading academic journal, Strategic Entrepreneurship Journal, and then later published in another article that was the runner-up for the 2009 Harvard Business Review McKinsey Award. Ultimately, this book introduces the results to the general public, which will likely find it to be both understandable and enlightening. This is definitely not some dry academic study.
Many of the innovators (or their companies) studied for the book will be familiar to most readers: Steve Jobs, Jeff Bezos, Michael Dell, Richard Branson, Howard Schultz (Starbucks), Scott Cook (Intuit), Peter Thiel (PayPal), Pierre Omidyar (eBay), Niklas Zennstrom (Skype) and many others.
Sure, all people are different (including innovators), but the authors' research shows that in most cases there are a number of common denominators within successful innovators. The flow of the authors' thinking is summarized nicely in a diagram on page 27. Simplifying, creative innovators (1) have the courage to innovate, as shown in their ability to challenge the status quo and take risks; (2) incorporate the behavioral skills of observing, questioning, networking and experimenting, which lead to (3) associative thinking that ultimately leads to innovative business ideas.
Interestingly, I think some of the book's chapter subtitles best summarize the various chapters' content. For example, rather than look at Chapter 2's formal title, "Discovery Skill # 1--Associating," consider the expressive subtitle, which is a quote from Steve Jobs: "Creativity is connecting things." Here are a few more chapter subtitles:
Chapter 3: "Question the unquestionable." (Ratan Tata, Tata Group)
Chapter 5: "What a person does on his own, without being stimulated by the thoughts and experiences of others, is even in the best of cases rather paltry and monotonous." (Albert Einstein, on collaboration/networking)
Chapter 6: "I haven't failed ... I've just found 10,000 ways that do not work." (Thomas Edison)
There's more, of course, but you get the idea. There are a number of helpful self-assessments in the book, along with a reasonably small number of clear charts and figures. All in all, the book is easy to read, hard to put down, and helpful not only for budding entrepreneurs, but also the rest of us.