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内容説明
It is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies os synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioural and gene-targeting methods. Leading experts in the best understood brain regions bring together the molecular, anatomical, functional, and behavioural data in authoritative integrated accounts. The chapters are organized in the same format, covering the neural elements, synaptic connections, basic circuits, physiology, neurotransmitters, neuromodulators, membrane properties, dendritic properties, and with a final section on how the circuits mediate specific behaviours. The uniform framework for each chapter enables the authors to higlight the principles that are common to all regions, as well as the adaptations unique to each, thus serving as a model for understanding the neural basis of behaviour.
Book Description
There has been rapid progress on the analysis of synaptic circuits in the past decade, requiring a new edition of this definitive text. Once again, leading authorities have joined to provide accounts of the best understood brain regions that are both in-depth and state-of-the-art. Each author uses the same format in covering the neural elements, synaptic connections, basic circuits, physiology and pharmacology, dendritic properties and functional implications, so that readers can easily compare different regions to recognize common principles and specific adaptations. A new chapter on the cochlear nucleus highlights the neural basis of audition, to accompany the account of vision in the retina, lateral geniculate and visual cortex, and of olfaction in the olfactory bulb and olfactory cortex. Chapters on the spinal cord, cerebellum and basal ganglia provide insights into the neural basis of sensorimotor integration. The chapter on the hippocampus is a new synthesis of the anatomy and physiology related to learning and memory. Common themes connecting the chapters are the recent studies of backpropagating impulses and active properties of dendrites; the increasing evidence for specific types of receptor and channel subunits and their properties in different parts of the neuron; the neuronal modeling; and the emerging evidence for canonical types of synaptic circuits mediating specific types of information processing that underlie behavior and cognition. The book will be essential reading for experimental and computational neuroscientists, neuropharmacologists, and cognitive neuroscientists, and for undergraduate, graduate, and medical students studying brain organization and brain function.
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