The second edition is usually better than the first one, and the first one was simply excellent! A great book, with a problem-based learning approach in mind, updated and with many new and important chapters (Protein Therapies, Drug Delivery Advances, Pharmacogenetics, among others). The good thing with this book is that any chapter deals with the necessary coverage of anatomy, physiology, pathology and so on before coming to the drugs facts. With the early med student in mind, the book will be useful for any health related career. The book is clear, is concise -notwithstanding comprehensive-, and with a complete set of drug facts tables at the end of most chapters. Simply said, the kind of book I'd liked to write myself.
One more thing: The book is brilliantly complemented by its companion book, "Principles of Pharmacology Workbook", by S. Farrell, a great account of more than 100 clinical cases regarding each chapter of the main book, with no less than five questions -and their corresponding answers- for every one of the cases. The ideal complement to make this couple of books the best pharmacology books in the scene today. I work very actively with both of them in teaching my own pharmacology courses.