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商品の説明
内容説明
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research since its first publication in 1985. This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet. This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Book Description
Since the publication of the second edition of Free Radicals in Biology and Medicine in 1989, the techniques of modern molecular, cellular, and structural biology have provided new data that have transformed scientific thinking about topics within free radical research. New reactive species, such as peroxynitrite, have been discovered to have a role in biological systems. Much of this third edition has been completely re-written and what remains from the second has been thoroughly updated. There are new chapters on antioxidant defence systems in bacteria, plants, and animals; the detection of free radicals; the role of antioxidants in aging, nutrition, disease, and therapy; and a new appendix on molecular biology. The chapter on oxidative stress and its consequences includes the damage and repair of DNA, proteins, and lipids, cytokines, and cell death (both apoptosis and necrosis).
Free radicals and other reactive species are now implicated in a wide range and number of diseases and the third edition covers their role in hypertension, diabetes, lung damage, cystic fibrosis, nervous system disorders, viral infections, and cancer. The toxicology chapter has been updated to include new sections on complex mixtures, nitro- and azo-compounds, and radiation. Erythrocytes, chloroplasts, the eye, the skin, reproduction, and exercise are covered as special cases of oxidative stress and antioxidant protection. Reactive species can act as useful biomolecules and this role is fully discussed. There is also an up-to-date introduction to free radical chemistry (as well as a basic chemistry appendix) and oxygen toxicity. Each major statement in the text is referenced. The authors have maintained the simplicity of approach and readability of the previous editions to make this book an invaluable companion to all those interested in the role of free radicals in life.
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カスタマーレビュー
Amazon.com で最も参考になったカスタマーレビュー (beta)
Amazon.com:
6件のカスタマーレビュー
18 人中、18人の方が、｢このレビューが参考になった｣と投票しています。
An excellent book for scientists
2000/5/29
形式:ペーパーバック
Free radical biology has become a big research area. This text is definitely a helpful tool for students and professionals alike. Halliwell and Gutteridge are both the "authorities" in free radical research. The book contains the basic concepts of metabolism, metal interactions, free radical formation, and antioxidation. The book then relates these processes (that is, oxidative and nitorsative stresses) to pathological events using various disease paradigms. The text contains good illustrations. It is an excellent reference material for everyone who is entering the field of free radical biology and medicine.
6 人中、6人の方が、｢このレビューが参考になった｣と投票しています。
Notes from an Oxymoron
2001/9/25
形式:ペーパーバック
Excellent book that provides a thorough grounding to the field. Keep the updated editions coming every few years and it will continue to stay at the top.
4 人中、4人の方が、｢このレビューが参考になった｣と投票しています。
Must have for free radical researchers
2008/6/18
形式:ペーパーバック
The 2007 edition of the "free radical bible". I strongly recommend this book to anyone currently in or seeking to enter the field of free radical biology. Are you a grad student writing quals or T32/F32? A post-doc going for PI/K99? A seasoned PI trying for the second R01 related to free radicals? One of the fastest ways for a proposal to get tossed is to propose questionable methods. Simply reviewing Pubmed is insufficient, since many papers also use questionable methods to assay for species such as superoxide or lipid peroxides. With this book one can easily reference the oxidative stress markers of interest and quickly determine a reliable method that is commonly accepted, as well as pinpoint the paper referenced to include in your own reference section.
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