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商品の説明
内容説明
The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologists fills this gap.
Experimental Design for Biologists explains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as "assumption controls," and "experimentalist controls." Furthermore, there are sections on establishing the experimental system, which include performing critical "system controls." Should all experimental plans be hypothesis driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologists is an essential source of theory and practical guidance in designing a research plan.
Experimental Design for Biologists explains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as "assumption controls," and "experimentalist controls." Furthermore, there are sections on establishing the experimental system, which include performing critical "system controls." Should all experimental plans be hypothesis driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologists is an essential source of theory and practical guidance in designing a research plan.
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最も参考になったカスタマーレビュー
1 人中、1人の方が、｢このレビューが参考になった｣と投票しています。
形式:ハードカバー
実験の組み立ては、院の間にラボで試行錯誤とトレーニングを積んで、鍛えられていくもの。中には、天才的なセンスを持っていて初めから何でもできる人がいるそうだけど、残念ながらお目にかかったことがない。そんなすごいセンスなんてない凡人がちょっとでもドーピングしようと思って、この本を読んだ。
コントロールの種類と区別に力点が置かれていて、ポジコンが一番重要で、なおかつ難しい、という点に納得。ネガコンも奥が深かった。
日々の実験に活かせているかというと、まだ疑問。
制限酵素の標的シークエンスを決める話は、ちょっとしたクイズのようでおもしろかった。
コントロールの種類と区別に力点が置かれていて、ポジコンが一番重要で、なおかつ難しい、という点に納得。ネガコンも奥が深かった。
日々の実験に活かせているかというと、まだ疑問。
制限酵素の標的シークエンスを決める話は、ちょっとしたクイズのようでおもしろかった。
Amazon.com で最も参考になったカスタマーレビュー (beta)
Amazon.com:
2件のカスタマーレビュー
11 人中、10人の方が、｢このレビューが参考になった｣と投票しています。
Badly Needed Advice to the Young Experimentor
2007/1/3
形式:ハードカバー
Students are taught to do expeiments in college, but these are carefully planned with the procedure and the results well tested. As the students move towards a graduate degree, they are expected to begin to do research of an original nature where neither the procedure nor the results are known in advance. This is a big step, and in general there has been little practical advice on how the student should proceed, just what is expected of him, how he is to work with his major professor, even how to know when he has found something.
This book, according to the author, is the result of a dinner with some fellow scientists where the wine flowed freely. They were lamenting about the differences in what students were being taught and the way that science was actually practiced.
The book lays out what happens to a real project. It begins with the first step of defining the problem to be studied, conducting research on what's been done on that problem, defining the experiments, controls, experimenting, confirming, peer review, using the results for predictions, and finally continuing the developmental effort into the future.
This is not a large book, but it provides a wealth of knowledge of the real world that the academic is preparing to enter. It is written in a light and entertaining style that doesn't hide the fact that the author has 'been there, done that.'
Highly Recommended!
This book, according to the author, is the result of a dinner with some fellow scientists where the wine flowed freely. They were lamenting about the differences in what students were being taught and the way that science was actually practiced.
The book lays out what happens to a real project. It begins with the first step of defining the problem to be studied, conducting research on what's been done on that problem, defining the experiments, controls, experimenting, confirming, peer review, using the results for predictions, and finally continuing the developmental effort into the future.
This is not a large book, but it provides a wealth of knowledge of the real world that the academic is preparing to enter. It is written in a light and entertaining style that doesn't hide the fact that the author has 'been there, done that.'
Highly Recommended!
3 人中、3人の方が、｢このレビューが参考になった｣と投票しています。
Good for advanced undergrad
2007/11/9
形式:ハードカバー
The discussions are simple enough to be understood at an undergraduate level, but may be good review for those who are creating experiments on their own for the first time. I would not recommend this for those more advanced in the scientific field, as it reiterates points that have most likely been taught at some point during grad school (or if they haven't been, they should be).
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