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内容説明
During development cells and tissues undergo changes in pattern and form that employ a wider range of physical mechanisms than at any other time in an organism's life. This book shows how physics can be used to analyze these biological phenomena. Written to be accessible to both biologists and physicists, major stages and components of the biological development process are introduced and then analyzed from the viewpoint of physics. The presentation of physical models requires no mathematics beyond basic calculus. Physical concepts introduced include diffusion, viscosity and elasticity, adhesion, dynamical systems, electrical potential, percolation, fractals, reaction-diffusion systems, and cellular automata. With full-color figures throughout, this comprehensive textbook teaches biophysics by application to developmental biology and is suitable for graduate and upper-undergraduate courses in physics and biology.
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カスタマーレビュー
最も参考になったカスタマーレビュー
1 人中、1人の方が、｢このレビューが参考になった｣と投票しています。
形式:ハードカバー
生物の個体発生を理解するためには、個々の細胞レベルでの遺伝子発現の状態
/変化を追うだけでは不十分である。特に、細胞同士が相互作用しながら変形/移
動する 形態形成の運動を理解するためには、物理学の知見が不可欠であること
に疑問の余地はない。
時には遺伝子発現のlayer、またあるときには細胞という物理的粒子が力学的
な相互作用 しながら変形/移動を繰り返す力学のlayer。少なくともこの二つの
layerを適切に往来し、 関連付けたところで初めて発生を理解できたと言えるの
ではないか。
この本は、発生における細胞の分化、形態形成の二つのトピックを柱に、分子
発生生物学と 物理学を橋渡ししようと試みる種々の研究をまとめたユニークな
作品に仕上がっている。
物理学に疎い読者のための簡単な物理の導入から始まり、発生の様々な局面を
物理学の 視点から解明しようとする試みが列挙される。
最終章では、著者がこの分野におけるこれまでの知見を総合し、原始の細胞の
凝 集体から現代の複雑で精密に制御された発生システムがどのようにして生ま
れてきたかを 推測する興味深い仮説が記述されている。
Differential expressionやsignal transductionのコレクションだけで発生を
語ることなんてできない！ と現状に不満を持っていた人間としては、これまで
自分の中に無かった視点で生命現象を 捉え直すことができ、発生の面白さを再
認識できたのが素直にうれしかった。
ただ、まだ発展途上の分野なので、すべての現象が物理でrigorousに記述され
てい るというわけではないのでその点注意が必要ではある(著者らも認識してい
る)。
美しいカラー図解が随所に出てきて読者の理解を手助けしてくれる。 前提と
する知識は、生物・物理・数学ともに大学初級レベル。 英語の記述は簡潔で平
易であり、魅力的な内容を楽しむことに集中できる。
/変化を追うだけでは不十分である。特に、細胞同士が相互作用しながら変形/移
動する 形態形成の運動を理解するためには、物理学の知見が不可欠であること
に疑問の余地はない。
時には遺伝子発現のlayer、またあるときには細胞という物理的粒子が力学的
な相互作用 しながら変形/移動を繰り返す力学のlayer。少なくともこの二つの
layerを適切に往来し、 関連付けたところで初めて発生を理解できたと言えるの
ではないか。
この本は、発生における細胞の分化、形態形成の二つのトピックを柱に、分子
発生生物学と 物理学を橋渡ししようと試みる種々の研究をまとめたユニークな
作品に仕上がっている。
物理学に疎い読者のための簡単な物理の導入から始まり、発生の様々な局面を
物理学の 視点から解明しようとする試みが列挙される。
最終章では、著者がこの分野におけるこれまでの知見を総合し、原始の細胞の
凝 集体から現代の複雑で精密に制御された発生システムがどのようにして生ま
れてきたかを 推測する興味深い仮説が記述されている。
Differential expressionやsignal transductionのコレクションだけで発生を
語ることなんてできない！ と現状に不満を持っていた人間としては、これまで
自分の中に無かった視点で生命現象を 捉え直すことができ、発生の面白さを再
認識できたのが素直にうれしかった。
ただ、まだ発展途上の分野なので、すべての現象が物理でrigorousに記述され
てい るというわけではないのでその点注意が必要ではある(著者らも認識してい
る)。
美しいカラー図解が随所に出てきて読者の理解を手助けしてくれる。 前提と
する知識は、生物・物理・数学ともに大学初級レベル。 英語の記述は簡潔で平
易であり、魅力的な内容を楽しむことに集中できる。
Amazon.com で最も参考になったカスタマーレビュー (beta)
Amazon.com:
5件のカスタマーレビュー
10 人中、10人の方が、｢このレビューが参考になった｣と投票しています。
Interdisciplinary concepts mediated between biology and physics
2006/3/20
形式:ハードカバー
The book by Forgacs and Newman on one hand introduces important biological concepts for physicists with interest in development, covering properties of isolated cells and principles of their regulation, the interaction between cells and cell and their environment, the formation of tissues by morphogenesis, principles underlying organogenesis, and evolutionary aspects important in development.
On the other hand the book also presents the complex interplay of physical processes under genetic control during development. It introduces fundamental physical concepts from point and continuum mechanics, thermodynamics and statistical mechanics (including critical phenomena), dynamical systems theory and reaction-diffusion systems. A major strength of the book is that physics is introduced through fundamental biological processes, thus using a framework familiar to biologists (and not the other way around, as in most texts on biophysics). The selection of examples captures many stages and processes during development.
The model description does not stop at the level of purely qualitative text description but includes the basic equations and their analysis, although this is done at an elementary level, requiring minimal knowledge of calculus (and the more complicated concepts are discussed in special "Boxes"). In this way the book also contains a short course in mathematical model formulation written for biologists. It does not aim at replacing existing books on developmental biology or biophysics but fits into the gap between both. It builds an interface between physicists and biologists in embryonic development and thereby should facilitate the reading of the more specialized books on developmental biology by physicists as well as the better understanding of physical principles and mathematical models and the role these play in biological systems, by biologists.
On the other hand the book also presents the complex interplay of physical processes under genetic control during development. It introduces fundamental physical concepts from point and continuum mechanics, thermodynamics and statistical mechanics (including critical phenomena), dynamical systems theory and reaction-diffusion systems. A major strength of the book is that physics is introduced through fundamental biological processes, thus using a framework familiar to biologists (and not the other way around, as in most texts on biophysics). The selection of examples captures many stages and processes during development.
The model description does not stop at the level of purely qualitative text description but includes the basic equations and their analysis, although this is done at an elementary level, requiring minimal knowledge of calculus (and the more complicated concepts are discussed in special "Boxes"). In this way the book also contains a short course in mathematical model formulation written for biologists. It does not aim at replacing existing books on developmental biology or biophysics but fits into the gap between both. It builds an interface between physicists and biologists in embryonic development and thereby should facilitate the reading of the more specialized books on developmental biology by physicists as well as the better understanding of physical principles and mathematical models and the role these play in biological systems, by biologists.
8 人中、8人の方が、｢このレビューが参考になった｣と投票しています。
Unique Perspective on the Relationship Between Physics and Biological Development
2006/5/31
形式:ハードカバー
While the course of embryological development is extremely complex, many of the component processes that go into shaping an embryo are strongly reminiscent of simpler physical phenomena which occur in nonliving materials. Some of these analogies are exact, the same physics applies in both cases. However, often the analogy is inexact or even misleading. Thus, while physical analogies can be extremely useful in understanding development, they also need to be approached with caution. Until now, no book-length overview has reviewed the many successes and pitfalls of a biological-physics approach to development and the material available in technical articles has been dispersed and often written in a technical jargon inaccessible to its target audience. Biological Physics of the Developing Embryo, fills this niche in a style that is easily comprehensible by advanced undergraduate biologists and physicists (and assumes minimal background on either side), while containing enough material that even senior researchers in development will learn a great deal. I've been working in the area for 15 years and found many ideas and references that were both new and valuable. The biological illustrations and examples are well chosen and cover almost every aspect of development in a clear, logical sequence. The consistent philosophy and approach of the two writers, one a physicist and bioengineer and the other a developmental biologist, helps organize an apparently heterogeneous collection of models and developmental mechanisms into a coherent story.
Because of its novelty and breadth, the book contains a number of minor errors, which will doubtless be corrected in a future edition. Overall, this is a path-breaking book, which I am recommending to all of my own students and to any colleagues interested in the question "What does physics have to say about development?"
Because of its novelty and breadth, the book contains a number of minor errors, which will doubtless be corrected in a future edition. Overall, this is a path-breaking book, which I am recommending to all of my own students and to any colleagues interested in the question "What does physics have to say about development?"
4 人中、4人の方が、｢このレビューが参考になった｣と投票しています。
A fascinating description of cell interactions and development
2006/10/27
形式:ハードカバー
"Biological Physics of the Developing Embryo" is a remarkable causal description of embryonic development as controlled by the interplay of physical and biomolecular processes. Based on their expertise in both theory and experiment (Forgacs is a condensed matter physicist and Newman was trained in physical chemistry, and each currently directs a program in cell and tissue biology), the authors present an engaging and original view of cell-cell interactions and multicellular morphogenesis and pattern formation. They offer a paradigm within which spatiotemporal cell behavior is explained by the concerted action of "generic" physical principles and specific genetic factors. Reading the book is made easy for both the physical and life scientist by the logic of its presentation: early development is presented according to the major stages familiar to the biologist in a clear fashion that also provides a short introduction to each event or process (cleavage, differentiation, gastrulation, segmentation, several kinds of organogenesis, fertilization) for the physicist. The physical modeling of each developmental episode is then discussed, making a smooth transition that is not overwhelming for the biologist. Each chapter ends with a short "perspective" which epitomizes the main conceptual lessons of the chapter resulting from the synthesis of experimental facts and relevant physical models. Books of this kind are rare, although badly needed, due to the large accumulation of facts. Not to be lost in the sea of data, an atheoretical descriptive analysis is no longer an option. Experimental results must be supplemented by systematic modeling for useful interpretations to emerge. The book by Forgacs and Newman teaches us how to accomplish this.
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